A single clone of T cells may identify 'self' from 'non-self' through different recognition mechanisms.
نویسندگان
چکیده
T cell antigen recognition is a special process. The complicated bindings between T cell receptor (TCR) or co-receptor (CD4 or CD8) and antigen peptide-major histocompatibility complex (pMHC) molecules have specific physiological significance. Recent reports show that different recognition models do exist in recognizing pMHCs by a single T cell. These different recognition mechanisms allow a single T cell to identify 'self' from 'non-self' and result in different biological consequence.
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ورودعنوان ژورنال:
- Frontiers in bioscience : a journal and virtual library
دوره 13 شماره
صفحات -
تاریخ انتشار 2008